Systems Biophysics of Gene Expression

Systems biophysics of gene expression.

Gene expression is a process central to any form of life. It involves multiple temporal and functional scales that extend from specific protein-DNA interactions to the coordinated regulation of multiple genes in response to intracellular and extracellular changes. This diversity in scales poses fundamental challenges to the use of traditional approaches to fully understand even the simplest gen...

Biophysics and systems biology

Biophysics at the systems level, as distinct from molecular biophysics, acquired its most famous paradigm in the work of Hodgkin and Huxley, who integrated their equations for the nerve impulse in 1952. Their approach has since been extended to other organs of the body, notably including the heart. The modern field of computational biology has expanded rapidly during the first decade of the twe...

Biophysics Precedes Biochemistry In Hox Gene Collinearity

Background: Hox gene collinearity is a universal phenomenon most emphatically observed during the development of vertebrate embryos. The last decade or so, a series of genetic engineering experiments have been performed including Hox gene deletions, duplications or transpositions. These experiments are illuminating and helpful to understand the mechanisms responsible for Hox gene collinearity. ...

O-41: Comparison of Vitrification Systems inHuman Oocytes and Evaluation of HSP A1Aand MnSOD Gene Expression Patterns

Background: The aim of this study was to compare two vitrification systems (Cryotop and OPS) on mouse MII oocytes and evaluate its effects on expression of heat shock protein A1A and MnSOD genes. Materials and Methods: Groups of about 15 oocytes without cumulus complexes (granulose, et. al.) were collected and exposed to equilibration and vitrification solutions before loading the oocytes into ...

Biophysics.